Post-transplant lymphoproliferative disease in tonsils of children with liver transplantation

Int J Pediatr Otorhinolaryngol. 2001 Apr 27;58(2):113-8. doi: 10.1016/s0165-5876(01)00415-3.

Abstract

Objective: To assess the incidence and characteristics of post-transplant lymphoproliferative disease (PTLD) in tonsils of the liver transplanted children.

Methods: All patients under 14 years of age recipients of a liver transplant at the institution and operated on for tonsillectomy under suspicion of malignancy were included in this study.

Results: Seven patients underwent surgery on their tonsils under suspicion of PTLD. One case of B-cell lymphoma, and three cases of polymorphic diffuse B-cell hyperplasia were found. This represents an incidence of 1.4% of PTLD in the tonsils of the 283 pediatric liver transplants performed at the hospital.

Conclusion: The incidence of PTLD in tonsils after liver transplantation is very low at the institution. However, it is very important to follow-up allograft recipients for early diagnosis of this entity.

MeSH terms

  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Liver Transplantation / adverse effects*
  • Lymphoma, B-Cell / etiology
  • Lymphoma, B-Cell / pathology
  • Lymphoproliferative Disorders / etiology*
  • Lymphoproliferative Disorders / pathology
  • Lymphoproliferative Disorders / surgery
  • Male
  • Palatine Tonsil / pathology*
  • Tonsillar Neoplasms / etiology
  • Tonsillar Neoplasms / pathology
  • Tonsillectomy