Abstract
Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure. The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Administration, Topical
-
Biopsy
-
Carcinoma in Situ / drug therapy
-
Carcinoma, Basal Cell / drug therapy
-
Carcinoma, Basosquamous / drug therapy
-
Carcinoma, Squamous Cell / drug therapy
-
Fluorouracil / administration & dosage
-
Fluorouracil / immunology
-
Fluorouracil / therapeutic use*
-
Humans
-
Hypersensitivity, Delayed*
-
Immunoglobulin G / analysis
-
Immunoglobulin M / analysis
-
Nitrobenzenes / immunology
-
Skin Neoplasms / drug therapy*
-
Skin Neoplasms / immunology
-
Skin Neoplasms / pathology
-
Skin Tests
Substances
-
Immunoglobulin G
-
Immunoglobulin M
-
Nitrobenzenes
-
Fluorouracil