Azithromycin and gentamicin therapy for the treatment of humans with brucellosis

Clin Infect Dis. 2001 Feb 1;32(3):506-9. doi: 10.1086/318503. Epub 2001 Jan 24.

Abstract

Ten patients with brucellosis were treated with azithromycin and gentamicin to assess the treatment's safety and efficacy. Seven patients had an excellent therapeutic response at the end of therapy; however, relapse was noted in 3. When relapse was considered in combination with an initial lack of efficacy, 5 patients (50%; 95% confidence interval, 18.7%-81.3%) did not respond to therapy; these results do not favor the use of azithromycin to treat brucellosis in humans.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / adverse effects
  • Azithromycin / therapeutic use*
  • Brucellosis / drug therapy*
  • Child
  • Drug Therapy, Combination
  • Female
  • Gentamicins / adverse effects
  • Gentamicins / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Safety
  • Treatment Failure
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Azithromycin