Comparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin B colloidal dispersion) and conventional deoxycholate formulations of amphotericin B in rabbits

Antimicrob Agents Chemother. 2001 Feb;45(2):612-5. doi: 10.1128/AAC.45.2.612-615.2001.

Abstract

The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a single dose and 3- to 30-fold less toxic after multiple dosing. These data are encouraging for the potential use of ABCD as an intrathecal treatment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / cerebrospinal fluid
  • Amphotericin B / pharmacokinetics*
  • Amphotericin B / pharmacology*
  • Amphotericin B / toxicity*
  • Animals
  • Antifungal Agents / cerebrospinal fluid
  • Antifungal Agents / pharmacokinetics*
  • Antifungal Agents / toxicity*
  • Biological Assay
  • Brain / pathology
  • Injections, Spinal
  • Male
  • Paecilomyces / drug effects
  • Rabbits
  • Spinal Cord / pathology

Substances

  • Antifungal Agents
  • Amphotericin B