Abstract
The metronidazole and albendazole susceptibility of 11 clinical isolates of Giardia duodenalis from France was determined using a neonatal mouse model and compared with the outcome in patients after standard metronidazole therapy (0.75 g/day for 5 days). All isolates found to be clinically resistant to metronidazole (4/11) exhibited an ID50 > 120 mg/kg in the mouse model. This therefore appears to be a suitable animal model in which to explore drug failures in human giardiasis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albendazole / pharmacology*
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Albendazole / therapeutic use
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Animals
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Animals, Newborn
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Anti-Infective Agents / pharmacology*
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Anti-Infective Agents / therapeutic use
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Antiprotozoal Agents / pharmacology*
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Antiprotozoal Agents / therapeutic use
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Feces / parasitology*
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Gerbillinae
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Giardia lamblia / drug effects*
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Giardiasis / drug therapy
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Humans
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Metronidazole / pharmacology*
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Metronidazole / therapeutic use
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Mice
Substances
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Anti-Infective Agents
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Antiprotozoal Agents
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Metronidazole
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Albendazole