Treatment of a vancomycin-resistant Enterococcus faecium ventricular drain infection with quinupristin/dalfopristin and review of the literature

J Infect. 2000 Jul;41(1):95-7. doi: 10.1053/jinf.2000.0665.

Abstract

Central nervous system infections involving vancomycin-resistant Enterococcus faecium (VREF) are infrequently described and pose significant therapeutic difficulties, because these organisms are intrinsically resistant to many antibiotics. We describe the use of intrathecal quinupristin/dalfopristin to treat a VREF-associated infection in a neuro--surgical patient.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / therapeutic use
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple*
  • Drug Therapy, Combination
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / pathogenicity*
  • Fatal Outcome
  • Female
  • Gram-Positive Bacterial Infections / drug therapy*
  • Humans
  • Hydrocephalus / therapy
  • Injections, Intravenous
  • Injections, Intraventricular
  • Injections, Spinal
  • Linezolid
  • Middle Aged
  • Oxazoles / therapeutic use
  • Oxazolidinones*
  • Subarachnoid Hemorrhage / therapy
  • Tomography, X-Ray Computed
  • Vancomycin / pharmacology
  • Vancomycin / therapeutic use
  • Ventriculoperitoneal Shunt / adverse effects
  • Virginiamycin / administration & dosage
  • Virginiamycin / analogs & derivatives*
  • Virginiamycin / therapeutic use

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazoles
  • Oxazolidinones
  • Virginiamycin
  • quinupristin
  • Vancomycin
  • Linezolid
  • dalfopristin