In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis

J M Rolain; M Maurin; A Bryskier; D Raoult

doi:10.1128/AAC.44.5.1391-1393.2000

In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis

Antimicrob Agents Chemother. 2000 May;44(5):1391-3. doi: 10.1128/AAC.44.5.1391-1393.2000.

Authors

J M Rolain¹, M Maurin, A Bryskier, D Raoult

Affiliation

¹ Unité des Rickettsies, CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France.

Abstract

In vitro activities of telithromycin compared to those of erythromycin against Rickettsia spp., Bartonella spp., Coxiella burnetii, and Ehrlichia chaffeensis were determined. Telithromycin was more active than erythromycin against Rickettsia, Bartonella, and Coxiella burnetii, with MICs of 0.5 microg/ml, 0.003 to 0.015 microg/ml, and 1 microg/ml, respectively, but was inactive against Ehrlichia chaffeensis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bartonella / drug effects*
Bartonella henselae / drug effects
Bartonella quintana / drug effects
Coxiella burnetii / drug effects
Ehrlichia chaffeensis / drug effects*
Humans
Ketolides*
Macrolides*
Microbial Sensitivity Tests
Rickettsia / drug effects*
Rickettsia conorii / drug effects
Rickettsia prowazekii / drug effects
Rickettsia rickettsii / drug effects
Rickettsia typhi / drug effects

Substances

Anti-Bacterial Agents
Ketolides
Macrolides
telithromycin