Abstract
Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.
MeSH terms
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Adult
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Animals
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Azithromycin / pharmacology
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Azithromycin / therapeutic use*
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Doxycycline / therapeutic use
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Drug Resistance, Microbial
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Female
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Humans
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Mice
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Microbial Sensitivity Tests
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Orientia tsutsugamushi / drug effects*
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Pregnancy
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Scrub Typhus / drug therapy*
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Scrub Typhus / microbiology
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Tetracycline Resistance
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Thailand
Substances
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Anti-Bacterial Agents
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Azithromycin
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Doxycycline