Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand

Antimicrob Agents Chemother. 1999 Nov;43(11):2817-8. doi: 10.1128/AAC.43.11.2817.

Abstract

Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / pharmacology
  • Azithromycin / therapeutic use*
  • Doxycycline / therapeutic use
  • Drug Resistance, Microbial
  • Female
  • Humans
  • Mice
  • Microbial Sensitivity Tests
  • Orientia tsutsugamushi / drug effects*
  • Pregnancy
  • Scrub Typhus / drug therapy*
  • Scrub Typhus / microbiology
  • Tetracycline Resistance
  • Thailand

Substances

  • Anti-Bacterial Agents
  • Azithromycin
  • Doxycycline