Antibiotic Class:

Monoxycarbolic acid

Antimicrobial Spectrum:

Streptococcus spp., Staphylococcus spp., H. influenzae, M. catarrhalis, Neisseria spp., P. multocida

Mechanism of Action:

Protein synthesis interruption by inhibition of isoleucine incorporation into growing bacterial protein chain.


No data


Protein binding: 95%

Serum half-life: 20-35 minutes

Adverse Effects:

Nares: local irritation, rhinitis

Skin: Rash, purities, headache

Other: taste alterations


Mupirocin Nasal Ointment (Parafin based) (1g)

Mupirocin Ointment (15, 30g)

Muprocin Ointment (Polyethylene glycol based) (22g)

Impetigo: Apply to affected area q 8 hours for 3 to 5 days

Nasal decolonization of MRSA: Apply to nares q 12h for 5 days

Disease state based dosing:

Renal failure:  Dosing adjustments not necessary

Hepatic failure:  Dosing adjustments not necessary



Drug Interactions:

No data available


Category B: No evidence of risk in humans but studies inadequate.

Monitoring requirements:

Patients should be monitored for symptoms of local irritation.

No laboratory parameters exist to monitor for efficacy or toxicity

Brand names/Manufacturer: