First choice

Alternatives

Comments

Drugs

Azithromycin 500mg PO q day

AND

Ethambutol 15-20 mg/kg/day PO

AND

Rifampin 600mg PO q day

PLUS or MINUS

Amikacin 7.5mg/kg IM or IV q 12h

OR Clarithromycin 250-500 mg PO

BID (Max 1g/day)

OR Amikacin Beads implanted at

the site of surgical debridement

Duration of therapy

is for a minimum of

12 months