Table 1. Comparative Activity of Antimicrobial Agents against Mycoplasma Pneumoniae
|
Antibiotic |
MIC90 (ug/ml) |
MIC50 (ug/ml) |
Range (ug/ml) |
|
Macrolides/ketolides |
|
|
|
|
Erythromycin |
< 0.004 |
< 0.004 |
< 0.004-.063 |
|
Clarithromycin |
< 0.031 |
< 0.004 |
< 0.004-.125 |
|
Azithromycin |
< 0.0027 |
0.002 |
< 0.002-0.0027 |
|
Roxithromycin |
0.0625 |
0.0313 |
0.0156-0.0625 |
|
Telithromycin |
< 0.015 |
< 0.015 |
|
|
Tetracyclines |
|
|
|
|
Tetracycline |
|
0.2 |
0.06-0.4 |
|
Doxycycline |
|
0.4 |
0.1-1.2 |
|
Fluroquinolones |
|
|
|
|
Ofloxacin |
1.0 |
|
0.5-1.0 |
|
Sparfloxacin |
0.063 |
|
0.031-0.063 |
|
Levofloxacin |
0.5 |
1.0 |
0.5-1.0 |
Table 2. MICs Distribution of 9 Antimicrobial Agents for 67 M. pneumoniae Isolated from 356 Adult Patients with CAP
or Upper RespiratoryTract Infections in Beijing Chao Yang Hospital 2008-2009
|
Antimicrobial agents |
No. of strains with MIC (μg/ml) of: |
||||||||||||||||
|
≤0.008 |
0.016 |
0.032 |
0.064 |
0.125 |
0.25 |
0.5 |
1 |
2 |
4 |
8 |
16 |
32 |
64 |
128 |
256 |
>256 |
|
|
Erythromycin |
21 |
|
|
|
|
|
|
|
|
|
|
|
1 |
|
6 |
14 |
25 |
|
Clarithromycin |
21 |
|
|
|
|
|
|
|
|
|
|
1 |
|
1 |
15 |
25 |
4 |
|
Azithromycin |
21 |
|
|
1 |
|
|
|
|
3 |
21 |
17 |
3 |
1 |
|
|
|
|
|
Ciprofloxacin |
1 |
|
|
|
1 |
15 |
48 |
2 |
|
|
|
|
|
|
|
|
|
|
Levofloxacin |
4 |
|
|
|
3 |
51 |
6 |
2 |
1 |
|
|
|
|
|
|
|
|
|
Gatifloxacin |
1 |
16 |
41 |
9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Moxifloxacin |
1 |
11 |
55 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tetracycline |
|
1 |
9 |
20 |
24 |
9 |
4 |
|
|
|
|
|
|
|
|
|
|
|
Minocycline |
|
2 |
13 |
29 |
16 |
4 |
3 |
|
|
|
|
|
|
|
|
|
|
TABLE 3: Dose and Duration of Recommended Antimicrobial Therapy for Mycoplasma pneumoniae Pneumonia [Download PDF]
|
Antibiotic |
Dose |
Duration |
|
Erythromycin |
Adults: 1-2 grams/day divided qid Children*: 40 mg/kg/day divided qid |
10 days
10 days
|
|
Clarithromycin |
Adults: 250-500 mg/day divided bid Children*: 15 mg/kg/day divided bid |
10 days
10 days |
|
Azithromycin |
Adults: 500 mg on day 1 followed by 250 mg/d on days 2-5
OR 500 mg/d
Children*: 10 mg/kg on day 1 followed by 5 mg/kg/day x 4 days |
5 days total
3 days total
5 days total |
|
Telithromycin |
Adults: 800 mg once daily |
5-10 days |
|
Moxfloxacin |
Adults only: 400 mg daily |
10 days
|
|
Levofloxacin |
Adults only: 500 mg/day |
7-14 days |
|
Tetracycline |
Adults: 1-2 grams/day divided qid Children > 7 years*: 25-50 mg/kg/day div q 6 hrs |
10 days
10 days |
|
Doxycycline |
Adults: 200 mg/d divided bid Children > 7 years*: 5 mg/kg/day div bid |
10 days
10 days |
*Daily dose in children should not exceed adult dose