Table 1. In Vitro Susceptibility of Aspergillus Fumigatus to Antifungal Agents
|
Drug |
MIC50 (ug/mL) |
MIC 90 (ug/mL) |
MIC RANGE (ug/mL) |
|
Amphotericin B |
1 |
1 |
0.5-4 |
|
Fluconazole |
>64 |
>64 |
>64 |
|
Miconazole |
4 |
16 |
1->64 |
|
Itraconazole |
1 |
2 |
0.25-2 |
|
Ravuconazole |
0.5 |
0.5 |
0.25-4 |
|
Voriconazole |
0.25 |
0.5 |
0.12-4 |
|
Posaconazole |
0.25 |
0.5 |
0.03-1 |
|
|
|
|
|
|
Caspofungin |
0.06 |
0.12 |
0.06-0.12 |
|
Anidulafungin |
0.03 |
0.06 |
0.004-0.12 |
|
Micafungin |
< 0.03 |
< 0.03 |
0.0078-0.03 |
|
|
|
|
|
|
Nystatin |
8 |
16 |
0.5->64 |
|
Liposomal nystatin |
2 |
2 |
ND |
|
Flucytosine |
>100 |
>100 |
0.5->64 |
|
Rifampin |
>1000 |
>1000 |
>1000 |
|
Terbinafine |
>16 |
>16 |
4->16 |
|
|
|
|
|
Collated from references (37, 126, 155, 156)
ND = No data
Table 2. In Vitro Susceptibility of Aspergillus Flavus to Antifungal Agents
|
Drug |
MIC50 (ug/mL) |
MIC 90 (ug/mL) |
MIC RANGE (ug/mL) |
|
Amphotericin B |
1 |
2 |
1-2 |
|
Fluconazole |
>64 |
>64 |
>64 |
|
Miconazole |
4 |
16 |
0.5->64 |
|
Itraconazole |
0.5 |
1 |
0.25-1 |
|
Ravuconazole |
0.5 |
1 |
0.12-1 |
|
Voriconazole |
0.5 |
1 |
0.06-1 |
|
Posaconazole |
0.25 |
0.5 |
0.12-1 |
|
|
|
|
|
|
Caspofungin |
0.06 |
0.12 |
0.03-0.5 |
|
Anidulafungin |
0.015 |
0.03 |
0.015-0.03 |
|
Micafungin |
0.0078 |
0.015 |
0.0078-0.015 |
|
|
|
|
|
|
Nystatin |
16 |
16 |
ND |
|
Liposomal nystatin |
2 |
4 |
ND |
|
Flucytosine |
>100 |
>100 |
10->100 |
|
Rifampin |
>1000 |
>1000 |
>1000 |
|
Terbinafine |
0.06 |
0.5 |
<0.03->16 |
|
|
|
|
|
Collated from references (37, 126, 155, 156)
Table 3. In Vitro Susceptibility of Aspergillus Terreus to Antifungal Agents
|
Drug |
MIC50 (ug/mL) |
MIC 90 (ug/mL) |
MIC RANGE (ug/mL) |
|
Amphotericin B |
2 |
2 |
1-4 |
|
Fluconazole |
>64 |
>64 |
>64 |
|
Miconazole |
4 |
16 |
0.5->64 |
|
Itraconazole |
0.5 |
ND |
0.25-0.5 |
|
Ravuconazole |
0.25 |
ND |
0.25-0.5 |
|
Voriconazole |
0.25 |
ND |
0.25-0.5 |
|
Posaconazole |
0.12 |
ND |
0.06-0.25 |
|
|
|
|
|
|
Caspofungin |
0.06 |
ND |
ND |
|
Anidulafungin |
0.06 |
ND |
ND |
|
Micafungin |
< 0.03 |
ND |
ND |
|
|
|
|
|
|
Nystatin |
16 |
16 |
ND |
|
Liposomal nystatin |
2 |
4 |
ND |
|
Flucytosine |
>100 |
>100 |
10->100 |
|
Rifampin |
>1000 |
>1000 |
>1000 |
|
Terbinafine |
0.06 |
0.5 |
<0.03->16 |
|
|
|
|
|
Collated from references (30, 99, 122, 123)
ND = No data