Sesquiterpene with an endoperoxide moeity
Active against all human malarial parasites, including multi-drug resistant Plasmodium falciparum strains.
Several proposed including the production of free radicals, other reactive metabolites, and altered membrane transport properties of membranes which may inhibit nutrient flow to the parasite.
Pharmacodynamics:
No data available
3.6mg/kg single dose in healthy volunteers; Half-life: 23.1 hours; Volume of distribution: 28.5 L/kg; Table 5
Cardiac: QTc prolongation, bradycardia
Neurologic: Neurotoxic (by mostly in-vitro data)
The recommended dose schedule is 3.2 mg beta-arteether/kg body weight on day 1, followed by 1.6 mg beta-arteether/kg on days 2 through 5.
Disease state based dosing:
No data available
Contraindications/Warnings/Precautions:
No data available
No data available
Not established. The World Health Organization currently advises against the use of artemisinins in the first trimester of pregnancy, unless in a lifesaving situation where other drugs are not suitable. In the second and third trimesters of pregnancy, artemisinin and its derivatives are not recommended unless alternative drug treatments are unsuitable.
None
Brand names/Manufacturer:
Information not currently available