Organism

 #  isolates

MIC₅₀ mg/ml

 MIC₉₀ mg/ml

Range or MIC (unspecified) mg/ml

Mycobacteria

Mycobacterium abscessus

1

>20

Mycobacterium acapulcensis

1

2.5

Mycobacterium asiaticum

10

>1

Mycobacterium aurum

1

10

Mycobacterium avium-intracellulare complex

35

52

523

16

<0.12

6.25

10

2.0

2

50

8.0

<0.12-4

0.78->100

0.25-16

Mycobacterium borstelense

1

>20

Mycobacterium bovis

38

 1   

Mycobacterium bovis-BCG

22

 1   

Mycobacterium celatum

2

128-256

Mycobacterium chelonae

15

60

16

>64

64

>64

>5

>64

0.25->256

Mycobacterium chelonae subsp. abscessus

1

20

>100

>100

50

50->100

Mycobacterium chelonae subsp. chelonae

20

>100

>100

25->100

Mycobacterium chelonae-fortuitum

5

>16

0.25->16

Mycobacterium chitae

2

10-20

Mycobacterium diernhoferi

1

20

Mycobacterium fallax

10

<0.25

4

<0.25-16

Mycobacterium flavescens

1

15

25

>1

Mycobacterium fortuitum

18

17

10

30

9

28

20

>64

5

>10

>8

64

50

>64

>20

100

16->64

>16

>8

0.125->256

12.5-100

Mycobacterium gastri

4

1

Mycobacterium gordonae

32

141

1

1^a

1^a

Mycobacterium haemophilum

17

3

0.5

1.0

0.5-2.0

0.25-1

Mycobacterium intracellulare

20

0.5

2

Mycobacterium kansasii

6

10

13

32

8

1

10

19

71

1.25

<0.25

1

0.25

0.2

1.0

1.25

0.5

1^a

3.13

0.1-0.5

1^a

1

0.125-0.5

0.025-3.13

Mycobacterium leprae

N/A

(<1)

Mycobacterium malmoense

1

47

1

1

Mycobacterium marinum

17

12

10

1

28

10

11

5

10

33

0.5

0.25

0.2

1

1^a

0.39

1.0^a

1^a

0.4-1.6

1.25

(1)

(1.56)

1.25-2.5

0.25-0.5

0.1-0.39

1.0^a

Mycobacterium microti

1

0.0025-0.040

Mycobacterium parafortuitum

1

1

10

50

Mycobacterium phlei

12

1

<0.32

0.6

Mycobacterium runyonii

1

>20

Mycobacterium scrofulaceum

19

19

51

1.56

0.78

12.5

6.25

0.1-6.25

>1

Mycobacterium simiae

3

2

28

>10^a

>10^a

>25

(>1)

Mycobacterium smegmatis

1

27

2

>16

>16

17

4->16

50

Mycobacterium szulgai

23

9

1

1

5.0^a

1.0^a

5.0 ^a

1.0 ^a

Mycobacterium terrae

7

64

5

1-5

>1

Mycobacterium thermoresistibile

1

1

1

1

1

1

Mycobacterium trivale

2

1^a

1^a

Mycobacterium tuberculosis

 rifampicin-sensitive

16

0.1

0.2

0.025-0.2

Mycobacterium tuberculosis

 rifampicin-resistant

6

100

100

50-100

Mycobacterium ulcerans

N/A

(0.005-0.2)

Mycobacterium vaccae

1

1

2.5

6.25

Mycobacterium xenopi

3

34

1

25

40

7

1

1^a

1

1^a

<1^u ,1.5^v

0.5-2

1

Organism

 #  isolates

MIC₅₀ mg/ml

 MIC₉₀ mg/ml

Range or MIC (unspecified) mg/ml

Mycobacteria

Mycobacterium avium complex

52

523

21

16

0.39

0.5

0.5

1.56

2.0

2

1.0

0.025-100

0.25-64

0.063-2.0

Mycobacterium bovis

N/A

(<2)

Mycobacterium celatum

2

2

0.5

8

Mycobacterium chelonae

18

N/A

N/A

60

32

64

(>2.0)

2-64

(32)

(>5)

Mycobacterium chelonae subsp. abscessus

20

12.5

25

3.13-25

Mycobacterium chelonae subsp. chelonae

20

12.5

50

3.13-50

Mycobacterium fallax

10

N/A

<0.25

1

<0.25--1

(<2)

Mycobacterium flavescens

N/A

(>5)

Mycobacterium fortuitum

17

28

N/A

20

30

1.25

1

3.13

>2.0

2.5

8

6.25

<0.25-8

(>5)

1.56-6.25

Mycobacterium gastri

N/A

(<1)

Mycobacterium gordonae

32

N/A

0.5^a

0.5^a

(<1)

Mycobacterium haemophilum

17

3

<0.03

<0.03

<0.03-0.06

0.25-1

Mycobacterium intracellulare

20

0.25

1

Mycobacterium kansasiii

10

13

21

32

19

0.075

<0.25

0.025

0.075

<0.25

0.1

0.25^a

0.5^a

<0.0125-0.2

Mycobacterium malmoense

1

0.12

Mycobaacterium marinum

17

12

N/A

10

<0.25

0.1

<0.25

0.1

0.5^a

(<1)

0.025-0.2

Mycobacterium microti

N/A

1

(<2)

0.0015-0.026

Mycobacterium paratuberculosis

8

0.06

0.03-0.25

Mycobacterium phlei

N/A

(<2)

Mycobacterium scrofulaceum

N/A

N/A

19

0.2

1.56

(<2)

(<1)

0.025-100

Mycobacterium simiae

3

N/A

1

1

>2^a

(>5)

0.5

8

Mycobacterium smegmatis

27

4

8

1-8

Mycobacterium szulgai

N/A

(>5)

Mycobacterium terrae

7

N/A

1.0^a

(0.5^b)

(<1)

Mycobacterium thermoresistibile 

1

1

2.0

0.5

Mycobacterium triviale

N/A

(<1)

Mycobacterium tuberculosis

 rifampicin-sensitive

16

180

0.025

0.5

0.025-0.05

0.5^a

Mycobacterium tuberculosis

 rifampicin-resistant

6

122

12.5

2.0

12.5

6.25-12.5

Mycobacterium ulcerans

N/A

(<2)

Mycobacterium xenopi

3

N/A

40

1

1

0.5

0.5^a

(<1)

0.5-2

0.5

0.1^d ,0.25^e

Feature

Rifampin 600 mg

(twice weekly)

Rifabutin 300 mg

(twice weekly)

Rifapentine 600 mg

(once weekly)

Bioavailability (%)

68

20

Unknown

Range of T_max

(time to C_max; hr)

1.5-2.0

2.5-4.0

5-6

Range of C_max (mcg/ml)

8-24

0.2-0.6

8-30

Effect of food

Decrease AUC 6%

Decrease C_max 36%

AUC & C_max unchanged;

T_max increased

Increase AUC 40-50%

Effect of antacids

None

None (didanosine)

Unknown

Major metabolic pathway

Deacetylation, hydrolysis to formyl derivatives

CYP3A-mediated hydroxylation, deacetylation

Deacetylation, hydrolysis to formyl derivatives

Range of serum half-life (hr)

2-5

32-67

14-18

Effect on CYP3A

Pronounced

Weak

Moderate

Auto-induction

Yes

Yes

No (or slight)

Effect on indinavir AUC (example of CYP3A induction)

92% decrease

34% decrease

70% decrease

Change in AUC when given with a CYP3A inhibitor

No effect

293% increase

No effect

Typical C_max (mcg/ml)

10.0

0.45

15.0

MIC in broth culture (mcg/ml)

0.15

0.06

0.04

Binding to plasma proteins (%)

85%

71-85%

97%