Table 1. Case Types of E. Corrodens Infections
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Central nervous system
brain abscess, meningitis, subdural empyema.
Head and neck
Eye, ear and nose: dacryocystitis, lacrimal abscess, conjunctivitis, orbital cellulitis, keratitis, otitis, nasal abscess.
Oral cavity: alveolar abscess, submandibular gland abscess, parotitis, peritonsillar abscess.
Upper and lower jaws, sinuses: chronic diffusing sclerosing osteomyelitis
of the mandible, maxillary osteitis, maxillary sinusitis, frontal sinusitis, cervicofacial actinomycosis.
Others: thyroiditis, thyroid abscess, bronchial arch cyst infections, mastoid osteitis, facial abscess, forehead cellulitis, facial wounds.
Chest
Pneumonia, empyema, pulmonary abscess, chest wall wounds, mediastinitis.
Abdominal cavity
Subdiaphragmatic abscess, pancreatic abscess, spleen abscess, abdominal abscess, appendicitis, sacral abscess, appendiceal abscess, esophagus empyema, pelvic abscess, retroperitoneal abscess, liver abscess, intraperitoneal abscess, abdominal wounds.
Cardiovascular system
Bacteremia/septicemia, endocarditis, vascular prosthesis infections.
Extremities
Bite wounds, paronychia, skin abscess, foot amputation stump, ankle arthritis, osteomyelitis.
Genitourinary and reproductive systems
Cervicitis, Bartholin's abscess, perirectal abscess, inguinal abscess, chorioamnionitis.
Table 2. Comparative Activity of Antimicrobial Agents Against E.
Corrodens*
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Antibiotics MIC50 (mg/ml) MIC90 (mg/ml) Range (mg/ml)
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Beta-lactams
Penicillin G 1.25 2.5 0.6-5
Ampicillin 0.5 1 0.5-4
Amoxicillin 0.5 0.5 0.125-0.5
clavulanate
Faropenem 0.25 0.25 0.125-0.25
Ertapenem 0.03 0.03 0.03
Imipenem 0.12 0.25 0.12-0.25
Meropenem 0.03 0.03 <0.013-0.03
Moxalactam 0.03 0.25 0.3-1
Cefotaxime 0.06 0.5 0.016-1
Cefoxitin 0.5 0.5 0.25-1
Mezlocillin 0.12 1 0.06-32
Ticarcillin 1 2 0.25-4
Loracarbef 4 4 0.015-8
Cefoperazone 0.5 4 0.25-32
Bacampicillin 2 4 2-8
Piperacillin 0.25 4 0.06-32
Cefprozil 8 8 0.06-8
Cephaloridine 16 16 8-32
Cephapirin 8 16 8-16
Cefazolin 8 16 4-32
Cephalothin 16 32 8-32
Cephalexin >64 >64 0.125->64
Cefaclor 8 32 4-32
Cefamandole 16 64 8-64
Cephradine 64 64 32-128
Cefadroxil >64 >64 0.25->64
Methicillin >16 >16 8->16
Dicloxacillin >128 >128 64->128
Quinolones
DU-6859a 0.002 0.004 0.001-0.008
Moxifloxacin 0.016 0.06 0.008-0.125[Bay 12-8039]
Ciprofloxacin 0.015 0.015 0.008-0.06Garenoxacin 0.06 0.125 <0.002-0.25
[BMS-284756]
Gatifloxacin 0.016 0.016 0.008-0.125
Gemifloxacin 0.06 0.06 0.03-0.06
Levofloxacin 0.015 0.015 0.015-0.03
Ofloxacin 0.015 0.03 0.008-0.125
Sparfloxacin 0.015 0.03 0.008-0.03
Trovafloxacin 0.06 0.06 0.008-0.25
Ofloxacin 0.03 0.03 0.015-0.125
Amifloxacin 0.003 0.06 0.15-1
Norflorxacin 0.03 0.06 0.15-0.5
Difloxacin 0.06 0.125 0.008-0.5
Enoxacin 0.06 0.125 0.03-2
Trovofloxacin 0.06 0.06 0.008-0.25
Nalidixic acid 1 2 0.25-16
Cinoxacin 2 2 0.5-16
Tetracyclines
Tetracycline 0.5 2.0 0.5-2.0
Doxycycline 1 2 0.25-4
Minocycline 0.25 1 0.125-1
GAR-936 0.5 4 0.25-4
Macrolides
Erythromycin 2 4 0.06-4
Azithromycin 1 2 0.06-4
Roxithromycin 32 32 4->32
Clarithromycin 2 4 0.125-4
Ketolides
RU-64004 0.25 0.5 0.03-1.0
Telithromycin 0.5 1 0.03-1.0
[HMR3647]
ABT-773 1 1 0.125-2
Lincosamides
Clindamycin 32 64 16->128
Lincomycin >100 >100 >100
Oxazolidinones
Linezolid 8 16 4-16
Glycopeptides
Vancomycin 32 64 4-64
Teicoplanin 32 32 8-32
Aminoglycosides
Streptomycin 8 16 8->16
Gentamicin 4 4 4-8
Nitroimidazoles
Metronidazole >100 >100 >100
Trimethoprim-sulfamethoxazole 0.125 0.25 0.06-0.5
Chloramphenicol 2 4 1->16
Rifampin 2 4 1-8
Synercid 8 16 0.06-16
[Quinpristin/dalfopristin]
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*Data based on various published reports.