Abstract
We report a case of Strongyloides stercoralis hyperinfection syndrome in a renal transplant recipient complicated by septic shock, acute respiratory distress syndrome, and Klebsiella pneumoniae superinfection. The patient was treated successfully with drotrecogin alfa (activated), parenteral ivermectin, albendazole, and piperacillin/tazobactam. This outcome suggests that drotrecogin alfa (activated) may be useful therapy for transplant recipients who develop severe sepsis or septic shock secondary to potentially lethal opportunistic infections.
MeSH terms
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Aged, 80 and over
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Albendazole / therapeutic use
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Animals
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Anti-Infective Agents / therapeutic use
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Drug Therapy, Combination
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Female
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Fibrinolytic Agents / administration & dosage
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Fibrinolytic Agents / therapeutic use*
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Humans
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Ivermectin / therapeutic use
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Kidney Transplantation / adverse effects*
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Klebsiella Infections / complications
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Penicillanic Acid / analogs & derivatives
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Penicillanic Acid / therapeutic use
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Piperacillin / therapeutic use
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Protein C / administration & dosage
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Protein C / therapeutic use*
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / therapeutic use
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Respiratory Distress Syndrome / drug therapy*
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Shock, Septic / drug therapy*
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Strongyloides stercoralis / drug effects*
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Strongyloidiasis / complications*
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Strongyloidiasis / drug therapy
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Strongyloidiasis / parasitology
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Superinfection / complications*
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Superinfection / microbiology
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Superinfection / parasitology
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Tazobactam
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Treatment Outcome
Substances
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Anti-Infective Agents
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Fibrinolytic Agents
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Protein C
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Recombinant Proteins
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Ivermectin
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Penicillanic Acid
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Albendazole
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drotrecogin alfa activated
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Tazobactam
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Piperacillin